The long-term goal of the Mattis Lab is to understand molecular mechanisms in medical liver diseases especially non-alcoholic fatty liver disease. To better understand liver diseases, the laboratory is using patient fibroblast cell lines, reprogrammed to induced pluripotent stem cells (iPSCs) and differentiating these to liver cells including hepatocytes, cholangiocytes, and experimentally to other cellular lineages. Cell culture experiments underway in the Mattis lab focus on identifying unique pathways in these diseases that drive mechanisms of disease. Our lab has other small projects including cholangiocarcinoma and hepatocellular carcinoma deep sequencing and analysis.